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Dr Hatim Husain Discusses HER2, Novel Therapy Exploration in Lung Cancer


Throughout the High quality Most cancers Care Alliance Summer season 2022 Nationwide Management Summit, Hatim Husain, MD, discusses how HER2 exploration in lung most cancers differs from that in breast most cancers, in addition to novel therapies being explored for HER2 and different illness targets.

Throughout the High quality Most cancers Care Alliance Summer season 2022 Nationwide Management Summit, Hatim Husain, MD, discusses how HER2 exploration in lung most cancers differs from that in breast most cancers, in addition to novel therapies being explored for HER2 and different illness targets.

Transcript

Is HER2 an space of ​​exploration in lung most cancers?

It is a essential query, as a result of the biomarkers for HER2 in lung most cancers are a bit completely different than breast most cancers. In lung most cancers, the biomarker of response is HER2 mutations, and that is compared to HER2 overexpression, or FISH [fluorescence in situ hybridization]in breast most cancers. HER2 mutations can happen in a subset of lung most cancers and could be outlined by insertions or level mutations, and so they can span the HER2 genes.

Are there any novel therapies being researched in lung most cancers that you’ve your eye on?

In lung most cancers, there are a number of novel therapies that I feel are necessary to learn about. Within the HER2 area, we do have an agent trastuzumab deruxtecan, which is exhibiting a fairly significant medical profit with response in sufferers who’ve this aberration of HER2 mutations. We even have an accredited agent within the KRAS G12C area, and I feel that is essential, as this was a beforehand unmet want. After which we do have rising information for a brand new class of molecules referred to as antibody-drug conjugates, the place we’re seeing profit throughout plenty of completely different targets in lung most cancers, together with Trop-2 and HER3 as properly, which will have an effect for sufferers as properly.

I feel that a part of the cornerstones of lung most cancers are testing for molecular drivers. It is a key part, not solely to have the check despatched, but in addition to attend for the check outcome when clinically acceptable to make therapy selections. And I additionally suppose that the longer term is sort of shiny with novel brokers which are being explored within the immune remedy area, in addition to novel molecularly guided therapies as properly, and likewise methods to suppose by means of what we could do for sufferers when sufferers haven’t got a selected molecular driver or predictive immune remedy biomarker as properly.

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