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FDG-PET May Predict Response to Neoadjuvant Therapy in Pancreatic Cancer – Consumer Health News


THURSDAY, Sept. 15, 2022 (HealthDay Information) — For sufferers with borderline resectable/domestically superior (BR/LA) pancreatic ductal adenocarcinoma (PDAC), preoperative fluorodeoxyglucose positron emission tomography (FDG-PET) could predict pathologic response to neoadjuvant remedy (NAT), in keeping with a examine revealed on-line Sept. 8 within the Journal of the Nationwide Complete Most cancers Community.

Amro M. Abdelrahman, MBBS, from the Mayo Clinic in Rochester, Minnesota, and colleagues reviewed 202 sufferers with resected BR/LA PDAC who underwent NAT with FDG-PET inside 60 days of resection to look at the function of preoperative FDG-PET for predicting NAT response and survival. Publish-NAT metabolic (FDG-PET) and biochemical (CA 19-9) responses have been in contrast as preoperative predictors of pathological responses.

The researchers discovered that 58 % of sufferers had optimization of CA 19-9 ranges post-NAT. In 51 % and 38 % of sufferers, main metabolic and pathological reactions have been recognized, respectively. The median recurrence-free survival (RFS) was 21 months, and total survival (OS) was 48.7 months. For predicting pathological response, metabolic response was superior to biochemical response. The one univariate preoperative predictor of OS was metabolic response (odds ratio, 0.25), and this was extremely correlated with pathological response in contrast with biochemical response alone. Metabolic response was the only largest impartial preoperative predictor of pathological response (odds ratio, 43.2) and of RFS and OS (hazard ratios, 0.37 and 0.21, respectively) after multivariate adjustment.

“With FDG-PET, we are able to inform sufferers how the most cancers responded to NAT earlier than going by way of main surgical resection,” Abdelrahman mentioned in a press release.

One writer disclosed monetary ties to the medical gadget and biopharmaceutical industries.

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